The laboratory is a joint research unit associating the CNRS (UMR5240), Claude Bernard Lyon 1 University and INSA of Lyon (University of Lyon), together with our industrial partner, around a common interest for the mechanisms of adaptation and pathogenesis of a large array of cellular microorganisms (archaea, amoebae, bacteria, fungi and yeasts).
Pathogenesis is a specific case of adaptation to a specific environment, that of a living organism: plant, insect, amoeba, man.
Within a campus dedicated to Environmental Biology (LyonTech La Doua), our research unit develops multi-discplinary approaches (biochemistry, genetics, molecular biology as well as various global approaches -genomics, transcriptomics, proteomics, metabolomics -, and mathematical modeling), to generate the integrative knowledge aimed at understanding the mechanisms of phenotypic adaptation in all such microorganisms.
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From outside ! Dr (α) Jekyl and Mister (β) Hyde. NusG homologs regulate transcription and coupled processes in all living organisms. The Escherichia coli (E. coli) two-domain paralogs NusG and RfaH have been shown in a recent Cell paper to bear identical N-terminal domains (NTDs) but dramatically different carboxy-t...