The laboratory is a joint research unit associating the CNRS (UMR5240), Claude Bernard Lyon 1 University and INSA of Lyon (University of Lyon), together with our industrial partner, around a common interest for the mechanisms of adaptation and pathogenesis of a large array of cellular microorganisms (archaea, amoebae, bacteria, fungi and yeasts).
Pathogenesis is a specific case of adaptation to a specific environment, that of a living organism: plant, insect, amoeba, man.
Within a campus dedicated to Environmental Biology (LyonTech La Doua), our research unit develops multi-discplinary approaches (biochemistry, genetics, molecular biology as well as various global approaches -genomics, transcriptomics, proteomics, metabolomics -, and mathematical modeling), to generate the integrative knowledge aimed at understanding the mechanisms of phenotypic adaptation in all such microorganisms.
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Where we show that almost all archaea have the ability to synthesize di- and tetraether lipids, which supports the view that functionalized membrane domains may be shared between all Archaea, hence that domain formation and membrane compartmentalization may have predated the separation of the three domains of life.