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Laboratoire - 03/10/2021

From outside ! Dr (α) Jekyl and Mister (β) Hyde. NusG homologs regulate transcription and coupled processes in all living organisms. The Escherichia coli (E. coli) two-domain paralogs NusG and RfaH have been shown in a recent Cell paper to bear identical N-terminal domains (NTDs) but dramatically different carboxy-terminal domains (CTDs), a β barrel in NusG and an α hairpin in RfaH.  

Activities - 01/10/2021

Teams - 14/09/2021

The basal mechanism described in this paper affects a wide range of species, and has been tested by extensive analysis of global high-throughput expression data.Altogether, these results confirm and provide a quantitative framework for the long-proposed notion that the discriminator sequence is a significant determinant of promoter supercoiling sensitivity.

Activities - 05/07/2021

The M2E team is under High Pressure

Activities - 30/06/2021