Michael Deghelt: Attaching the Outer Membrane to the Peptidoglycan Enables Vital Periplasmic Pressure Buildup (Séminaire invité MTSB)

Michael Deghelt is currently Senior Scientist at the De Duve institute UCL Belgium. (Jean-François Collet lab, de Duve Institute, UCLouvain, Belgium Bacterial cell envelope of E. coli – fundamental and industrial aspects)

Bacterial cell envelope of Escherichia coli. Investigation of the biophysical parameters governing the bacterial cell architecture (i.e., structural roles of the membranes and the peptidoglycan). My projects investigate the roles of the connections between the membranes and the peptidoglycan layer and their role in the preservation of the osmotic pressure within the compartments. I also study how the modification of the composition of the membranes and the peptidoglycan influence the survival of the bacteria to several stresses and how the cell envelopes of two sibling cells are separated during division. Finally, my work aims to understand how membrane permeability can be facilitated in the context of new antibiotics discovery.